- Sand Gravel & Aggregate, Lexington
- Sandblasting, Lexington - General Contractors
- Sandwich Shop Restaurants, Lexington
- Satellite Dish Antennas & Equipment Dealers, Lexington
- Scales Retail, Lexington
- Seafood Restaurants, Lexington
- Secondary Schools, Lexington
- Security & Commodity Brokers, Lexington
- Security Brokers & Dealers, Lexington
- Senior Citizens Housing, Lexington
- Senior Citizens Service & Health Organizations, Lexington
- Septic Tank Installation & Repair, Lexington - Septic Systems
- Septic Tank Pumping & Cleaning, Lexington - Septic Systems
- Septic Tanks & Septic Systems Contractors, Lexington - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Shopping & Shopping Services, Lexington
- Shopping Services, Lexington
- Siding Contractors, Lexington - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Snack Foods, Lexington
- Snacks & Desserts, Lexington
- Social Services & Welfare, Lexington
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- Societies & Foundation Associations, Lexington
- Sod & Sodding Service, Lexington
- Speciality Food Stores, Lexington
- Specialty Animal Services, Lexington
- Specialty Stores, Lexington
- Sporting Goods Stores, Lexington
- Sports Bars & Lounges, Lexington
- Sports Medicine, Lexington - Doctors, Physicians & Surgeons
- Staffing & Support Services, Lexington
- State Government, Lexington
- Steel Fabrication & Processing Equipment, Lexington
- Stock & Bond Brokers & Dealers, Lexington
- Stocks & Bond Brokers, Lexington
- Store Fixtures & Display Equipment, Lexington
- Store Fronts, Lexington - Storefront
- Submarine Sandwich Restaurants, Lexington
- Substance Abuse Clinics, Lexington - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Swimming Pool, Sauna & Spa Contractors, Lexington
- Swimming Pools Contractors, Lexington - Install Inground - Above Ground Pools
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