- Safety & Security Systems & Consultants, Holdrege
- Salvage Yards, Junk Yards & Wrecker Service, Holdrege
- Sandblasting, Holdrege - General Contractors
- Sandwich Shop Restaurants, Holdrege
- Sanitation Consultants, Holdrege
- Satellite Dish Antennas & Equipment Dealers, Holdrege
- Screen Printing, Holdrege
- Secondary Schools, Holdrege
- Security & Commodity Brokers, Holdrege
- Security & Surveillance System & Equipment, Holdrege
- Security Alarm Systems - Home & Business, Holdrege
- Security Brokers & Dealers, Holdrege
- Security Control Systems & Monitoring, Holdrege - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Holdrege
- Seeds & Bulbs Wholesale & Growers, Holdrege
- Senior Citizens Housing, Holdrege
- Senior Citizens Service & Health Organizations, Holdrege
- Septic Tank Installation & Repair, Holdrege - Septic Systems
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- Septic Tank Pumping & Cleaning, Holdrege - Septic Systems
- Septic Tanks & Septic Systems Contractors, Holdrege - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing & Yarn Stores & Supplies, Holdrege
- Shopping & Shopping Services, Holdrege
- Siding Contractors, Holdrege - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Holdrege
- Snacks & Desserts, Holdrege
- Social Services & Welfare, Holdrege
- Societies & Foundation Associations, Holdrege
- Special Interest Schools Or Instruction, Holdrege
- Specialty Stores, Holdrege
- Sporting Goods Stores, Holdrege
- Sports Medicine, Holdrege - Doctors, Physicians & Surgeons
- State Government, Holdrege
- Steak House Restaurants, Holdrege
- Stocks & Bond Brokers, Holdrege
- Submarine Sandwich Restaurants, Holdrege
- Surveyor Services, Holdrege - Surveying Service
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